Large Scale Correlation Screening

TL;DR

This paper develops asymptotic theory for correlation screening methods in high-dimensional data, enabling scalable identification of highly correlated variables across different applications, with validation on gene-expression data.

Contribution

It introduces a theoretical framework for threshold-based correlation screening, addressing phase transition phenomena and false positive rates in high-dimensional settings.

Findings

Asymptotic expressions for mean number of discoveries

Identification of phase transition thresholds

Validation on large gene-expression dataset

Abstract

This paper treats the problem of screening for variables with high correlations in high dimensional data in which there can be many fewer samples than variables. We focus on threshold-based correlation screening methods for three related applications: screening for variables with large correlations within a single treatment (autocorrelation screening); screening for variables with large cross-correlations over two treatments (cross-correlation screening); screening for variables that have persistently large auto-correlations over two treatments (persistent-correlation screening). The novelty of correlation screening is that it identifies a smaller number of variables which are highly correlated with others, as compared to identifying a number of correlation parameters. Correlation screening suffers from a phase transition phenomenon: as the correlation threshold decreases the number of discoveries increases abruptly. We obtain asymptotic expressions for the mean number of discoveries and the phase transition thresholds as a function of the number of samples, the number of variables, and the joint sample distribution. We also show that under a weak dependency condition the number of discoveries is dominated by a Poisson random variable giving an asymptotic expression for the false positive rate. The correlation screening approach bears tremendous dividends in terms of the type and strength of the asymptotic results that can be obtained. It also overcomes some of the major hurdles faced by existing methods in the literature as correlation screening is naturally scalable to high dimension. Numerical results strongly validate the theory that is presented in this paper. We illustrate the application of the correlation screening methodology on a large scale gene-expression dataset, revealing a few influential variables that exhibit a significant amount of correlation over multiple treatments.