Determination of Different Biological Factors on the Base of Dried Blood Spot Technology

TL;DR

This study develops mathematical algorithms to analyze dried blood spot data, enabling accurate estimation of initial blood volume and analyte concentrations for clinical use.

Contribution

It introduces novel algorithms for interpreting dried blood spot data to determine blood volume and analyte levels, improving diagnostic accuracy.

Findings

Algorithms successfully estimate blood volume from dried blood spots

Accurate calculation of analyte concentrations achieved

Analysis based on a large patient database

Abstract

It is well-known that distinct biological indices (analytes) have distinct variability. We try to use some mathematical algorithms to pick out a set of blood parameters which give an opportunity to retrieve the initial volume of the blood spotted, and use it to calculate exact concentrations of analyts interesting to a physician. For our analysis we used the database of biochemical blood parameters obtained in Russian Scientific Center of Roentgen-Radiology during 1995-2000, which includes more than 30000 of patients.