Tree-valued Fleming-Viot dynamics with mutation and selection

TL;DR

This paper introduces a tree-valued extension of the Fleming-Viot process incorporating mutation and selection, capturing genealogical relations and analyzing long-term behavior with new mathematical tools.

Contribution

It develops a well-posed martingale problem for the tree-valued Fleming-Viot process with mutation and selection, and establishes ergodicity and genealogical distance properties.

Findings

Constructed the TFVMS process via finite population models.

Proved ergodicity of the process under certain conditions.

Derived an expansion for genealogical distances in the presence of weak selection.

Abstract

The Fleming-Viot measure-valued diffusion is a Markov process describing the evolution of (allelic) types under mutation, selection and random reproduction. We enrich this process by genealogical relations of individuals so that the random type distribution as well as the genealogical distances in the population evolve stochastically. The state space of this tree-valued enrichment of the Fleming-Viot dynamics with mutation and selection (TFVMS) consists of marked ultrametric measure spaces, equipped with the marked Gromov-weak topology and a suitable notion of polynomials as a separating algebra of test functions. The construction and study of the TFVMS is based on a well-posed martingale problem. For existence, we use approximating finite population models, the tree-valued Moran models, while uniqueness follows from duality to a function-valued process. Path properties of the resulting process carry over from the neutral case due to absolute continuity, given by a new Girsanov-type theorem on marked metric measure spaces. To study the long-time behavior of the process, we use a duality based on ideas from Dawson and Greven [On the effects of migration in spatial Fleming-Viot models with selection and mutation (2011c) Unpublished manuscript] and prove ergodicity of the TFVMS if the Fleming-Viot measure-valued diffusion is ergodic. As a further application, we consider the case of two allelic types and additive selection. For small selection strength, we give an expansion of the Laplace transform of genealogical distances in equilibrium, which is a first step in showing that distances are shorter in the selective case.