The effects of bio-fluid on the internal motion of DNA

TL;DR

This paper models the internal motions of DNA immersed in bio-fluid using gauge fluid lagrangian, revealing how bio-fluid influences DNA dynamics, with distinct behaviors for single and double stranded DNA.

Contribution

It introduces a unified gauge fluid lagrangian framework to analyze DNA motion in bio-fluid, accounting for different behaviors of single and double stranded DNA.

Findings

Single stranded DNA exhibits solitonic wave behavior in bio-fluid.

Double stranded DNA acts as a harmonic oscillator influenced by fluid velocity.

The model explains amplitude variations in DNA motion within bio-fluid.

Abstract

The internal motions of DNA immersed in bio-fluid are investigated. The interactions between the fragments of DNA and the surrounding bio-fluid are modeled using the gauge fluid lagrangian. In the model, the bio-fluid is coupled to the standard gauge invariant bosonic lagrangian describing the DNA. It is shown that at non-relativistic limit various equation of motions, from the well-known Sine-Gordon equation to the simultaneous nonlinear equations, can be constructed within a single framework. The effects of bio-fluid are investigated for two cases : single and double stranded DNA. It is argued that the small and large amplitudes of a single stranded DNA motion immersed in bio-fluid can be explained in a natural way within the model as a solitonic wave regardless with the fluid velocity. In contrary the double stranded DNA behaves as regular or damped harmonic oscillator and is highly depending on the fluid velocity.