Epigenetic Tracking: a model for all biology

TL;DR

Epigenetic Tracking is a comprehensive model simulating biological development and phenomena like aging and cancer, linking genetic and cellular properties to organism complexity, aiming to serve as a universal biological framework.

Contribution

This work presents a structured biological perspective on the Epigenetic Tracking model, integrating development, aging, and carcinogenesis within a unified computational framework.

Findings

Reproduces simplified biological phenomena such as development and aging.

Models cancer processes within the cellular system.

Links gene and cell properties to organism complexity.

Abstract

"Epigenetic Tracking" is a model of systems of biological cells, able to generate arbitrary 2 or 3-dimensional cellular shapes of any kind and complexity (in terms of number of cells, number of colours, etc.) starting from a single cell. If the complexity of such structures is interpreted as a metaphor for the complexity of biological structures, we can conclude that this model has the potential to generate the complexity typical of living beings. It can be shown how the model is able to reproduce a simplified version of key biological phenomena such as development, the presence of "junk DNA", the phenomenon of ageing and the process of carcinogenesis. The model links properties and behaviour of genes and cells to properties and behaviour of the organism, describing and interpreting the said phenomena with a unified framework: for this reason, we think it can be proposed as a model for all biology. The material contained in this work is not new: the model and its implications have all been described in previous works from a computer-science point of view. This work has two objectives: 1) To present the whole theory in an organic and structured way and 2) To introduce Epigenetic Tracking from a biological perspective. The work is divided into six parts: the first part is the introduction; the second part describes the cellular model; the third part is dedicated to the evo-devo method and transposable-elements; the fourth part deals with junk DNA and ageing; the fifth part explores the topic of cancer; the sixth part draws the conclusions.