Lattice Models of Nonequilibrium Bacterial Dynamics

TL;DR

This paper introduces a lattice model for bacterial run-and-tumble motion, providing exact solutions and a field theoretic approach to analyze nonequilibrium dynamics and crowding effects, bridging discrete and continuum models.

Contribution

The authors develop a lattice-based model with analytical solutions for run-and-tumble dynamics, connecting it to continuum theories and exploring crowding interactions.

Findings

Exact solutions for non-interacting and zero-range models

Derivation of continuum fluctuating hydrodynamics

Analysis of steady states and stability under crowding

Abstract

We study a model of self propelled particles exhibiting run and tumble dynamics on lattice. This non-Brownian diffusion is characterised by a random walk with a finite persistence length between changes of direction, and is inspired by the motion of bacteria such as E. coli. By defining a class of models with multiple species of particle and transmutation between species we can recreate such dynamics. These models admit exact analytical results whilst also forming a counterpart to previous continuum models of run and tumble dynamics. We solve the externally driven non-interacting and zero-range versions of the model exactly and utilise a field theoretic approach to derive the continuum fluctuating hydrodynamics for more general interactions. We make contact with prior approaches to run and tumble dynamics off lattice and determine the steady state and linear stability for a class of crowding interactions, where the jump rate decreases as density increases. In addition to its interest from the perspective of nonequilibrium statistical mechanics, this lattice model constitutes and efficient tool to simulate a class of interacting run and tumble models relevant to bacterial motion, so long as certain conditions (that we derive) are met.