Time-resolved and time-scale adaptive measures of spike train synchrony

TL;DR

The paper introduces the SPIKE-distance, a new time-resolved, parameter-free measure of spike train synchrony that is sensitive to spike coincidences and suitable for analyzing multiple spike trains.

Contribution

It presents the SPIKE-distance, a novel measure that complements existing methods by capturing spike coincidences while maintaining time-scale independence and ease of visualization.

Findings

Effective in simulated data

Validated with real data

Sensitive to spike coincidences

Abstract

A wide variety of approaches to estimate the degree of synchrony between two or more spike trains have been proposed. One of the most recent methods is the ISI-distance which extracts information from the interspike intervals (ISIs) by evaluating the ratio of the instantaneous firing rates. In contrast to most previously proposed measures it is parameter free and time-scale independent. However, it is not well suited to track changes in synchrony that are based on spike coincidences. Here we propose the SPIKE-distance, a complementary measure which is sensitive to spike coincidences but still shares the fundamental advantages of the ISI-distance. In particular, it is easy to visualize in a time-resolved manner and can be extended to a method that is also applicable to larger sets of spike trains. We show the merit of the SPIKE-distance using both simulated and real data.