Yield enhancement in whispering gallery mode biosensors: microfluidics and optical forces

TL;DR

This paper introduces a microfluidic WGM biosensing system that significantly accelerates molecule detection and improves yield by leveraging optical forces and flow control, outperforming traditional diffusion-based methods.

Contribution

The study demonstrates a novel integration of microfluidics and optical forces in WGM biosensors, achieving rapid detection and high yield at femtomolar analyte concentrations.

Findings

Detection time reduced from over 100 minutes to less than 10 seconds.

Device yield increased from under 5% to 70.6%.

Enhanced sensing performance at femtomolar concentrations.

Abstract

A microfluidic whispering gallery mode (WGM) biosensing system is proposed for enhanced delivery and detection of target molecules. A microtoroid resonator coupled to a tapered optical fiber is immersed within a microfluidic channel, and supplied with target molecules at various flow rates. We show through Monte Carlo simulations that the flow characteristics and resonantly enhanced optical forces of the sensor substantially improve both the sensing time and yield. When compared to a diffusion-limited sensing modality, the average time required to detect a single molecule is reduced from more than 100 minutes to less than 10 seconds, and the overall yield of the device is enhanced from less than 5% to a maximum of 70.6% for femtomolar concentrations of analyte.