Pacer cell response to periodic Zeitgebers

TL;DR

This paper models the mammalian circadian clock as a phase oscillator influenced by light-dark cycles, using a circle map to analyze entrainment, synchronization, and resonance phenomena observed in biological systems.

Contribution

It introduces a simplified circle map model for Pacer cell response to periodic Zeitgebers, capturing key dynamical behaviors like entrainment and resonance.

Findings

Identification of Arnol'd tongues indicating resonance regions

Demonstration of entrainment and synchronization phenomena

Relation of model dynamics to biological observations

Abstract

Almost all organisms show some kind of time periodicity in their behavior. Especially in mammals the neurons of the suprachiasmatic nucleus form a biological clock regulating the activity-inactivity cycle of the animal. This clock is stimulated by the natural 24-hour light-dark cycle. In our model of this system we consider each neuron as a so called phase oscillator, coupled to other neurons for which the light-dark cycle is a Zeitgeber. To simplify the model we first take an externally stimulated single phase oscillator. The first part of the phase interval is called the active state and the remaining part is the inactive state. Without external stimulus the oscillator oscillates with its intrinsic period. An external stimulus, be it from activity of neighboring cells or the periodic daylight cycle, acts twofold, it may delay the change form active to inactive and it may advance the return to the active state. The amount of delay and advance depends on the strength of the stimulus. We use a circle map as a mathematical model for this system. This map depends on several parameters, among which the intrinsic period and phase delay and advance. In parameter space we find Arnol'd tongues where the system is in resonance with the Zeitgeber. Thus already in this simplified system we find entrainment and synchronization. Also some other phenomena from biological experiments and observations can be related to the dynamical behavior of the circle map.