Localised IR spectroscopy of hemoglobin
Fiona Yarrow, James H. Rice
TL;DR
This paper introduces a high-resolution IR spectroscopy method for hemoglobin using an innovative AFM-based setup, enabling detailed analysis of micron-sized protein features beyond standard IR capabilities.
Contribution
The study presents a novel experimental arrangement combining IR spectroscopy with AFM for enhanced spatial resolution in protein analysis.
Findings
Achieved higher spatial resolution than standard IR spectroscopy.
Successfully obtained IR absorption spectra of micron-sized hemoglobin features.
Demonstrated the potential for detailed protein characterization at microscale.
Abstract
IR absorption spectroscopy of hemoglobin was performed using an IR optical parametric oscillator laser and a commercial atomic force microscope in a novel experimental arrangement based on the use of a bottom-up excitation alignment. This experimental approach enables detection of protein samples with a resolution that is much higher than that of standard IR spectroscopy. Presented here are AFM based IR absorption spectra of micron sized hemoglobin features
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Taxonomy
TopicsSpectroscopy Techniques in Biomedical and Chemical Research · Spectroscopy and Quantum Chemical Studies · Protein Interaction Studies and Fluorescence Analysis