Analytical expressions for stopping-power ratios relevant for accurate dosimetry in particle therapy

TL;DR

This paper derives analytical formulas for stopping-power ratios in particle therapy, enhancing dosimetry accuracy by considering various ions, energy ranges, and spread out Bragg peaks, supported by Monte Carlo simulations.

Contribution

It provides a comprehensive theoretical study and new analytical expressions for STPRs applicable to multiple ion types and therapy conditions, expanding beyond previous carbon ion focus.

Findings

STPR depends mainly on ion energy, not charge or position.

Deviations up to 2% found between different stopping-power data sets.

Secondary particle spectra have minimal impact on STPR.

Abstract

In particle therapy, knowledge of the stopping-power ratios (STPRs) of the ion beam for air and water is necessary for accurate ionization chamber dosimetry. Earlier work has investigated the STPRs for pristine carbon ion beams, but here we expand the calculations to a range of ions (1 <= z <= 18) as well as spread out Bragg peaks (SOBPs) and provide a theoretical in-depth study with a special focus on the parameter regime relevant for particle therapy. The Monte Carlo transport code SHIELD-HIT is used to calculate complete particle-fluence spectra which are required for determining STPRs according to the recommendations of the International Atomic Energy Agency (IAEA). We confirm that the STPR depends primarily on the current energy of the ions rather than on their charge z or absolute position in the medium. However, STPRs for different sets of stopping-power data for water and air recommended by the International Commission on Radiation Units & Measurements (ICRU) are compared, including also the recently revised data for water, yielding deviations up to 2% in the plateau region. In comparison, the influence of the secondary particle spectra on the STPR is about two orders of magnitude smaller in the whole region up till the practical range. The gained insights enable us to propose an analytic approximation for the STPR for both pristine and SOBPs as a function of penetration depth, which parametrically depend only on the initial energy and the residual range of the ion, respectively.