Dosage-dependent NF-kB oscillatory and heterogeneous dynamics in response to E. Coli Lipopolyssachride stimulation
Jaewook Joo, Jens Poschet, Catherine S. Branda, Bryan Carson, and Anup, Singh
TL;DR
This study investigates how varying doses of E. Coli lipopolysaccharide influence NF-kB signaling dynamics, revealing oscillatory and heterogeneous responses that depend on stimulus strength.
Contribution
It introduces a detailed analysis of dose-dependent NF-kB dynamics, highlighting oscillatory patterns and heterogeneity in cellular responses to bacterial components.
Findings
NF-kB exhibits oscillatory behavior depending on LPS dose.
Cellular responses are heterogeneous at different stimulation levels.
Dose influences the amplitude and frequency of NF-kB oscillations.
Abstract
This paper has been withdrawn by the author.
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Taxonomy
TopicsNF-κB Signaling Pathways · Immune Response and Inflammation · Genomics, phytochemicals, and oxidative stress