How is the Monoclonal Antibodies Kinetic Affected by Changes of Their Physical Parameters?

TL;DR

This study investigates how physical parameters like radius, mass, and density of monoclonal antibodies influence their transport kinetics in blood flow, using numerical simulations of particle motion in laminar flow.

Contribution

It provides a numerical analysis of how changes in physical parameters affect monoclonal antibody transport in blood vessels, which was not previously detailed.

Findings

Kinetics increase with higher vessel pressure.

Reducing antibody radius enhances transport speed.

Increasing antibody density also accelerates kinetics.

Abstract

The study of monoclonal antibodies (MAb) is a field of great interest to science medicine, for example, anti-TNF agents (infliximab and adalimumab) represent an important tool for the management of autoimmune and inflammatory disorders. In this work we focus on the physical description of the transport kinetics of MAb in a fluid with laminar flow and parabolic profile. To simulate the kinetics of the MAb, standard equations were solved numerically (using The Verlet algorithm) to calculate the motion of a particle with a spherically symmetric inside of parabolic laminar flow, in order to find the time evolution of the antibody velocity in blood plasma in function of the increase of the radius, mass and density of the MAb, and the fluid pressure in blood vessels. In the case of we fixed the value of the antibody density, their kinetics increased when the pressure in the vessels increased. When we fixed the pressure in the vessels we found: if we reduce the antibody radius their kinetics increased, and when we increase antibody density we found that their kinetics also increased.