Realization and Properties of Biochemical-Computing Biocatalytic XOR Gate Based on Signal Change

TL;DR

This paper presents a biochemical XOR gate based on biocatalytic reactions, modeling its behavior and optimizing its performance through experimental modifications to improve signal detection and noise properties.

Contribution

It introduces a novel biochemical XOR gate using competing reactions and develops a model for its evaluation and optimization.

Findings

Model accurately describes gate behavior

Modifications improve signal clarity

Optimized gate reduces noise amplification

Abstract

We consider a realization of the XOR logic gate in a system involving two competing biocatalytic reactions, for which the logic-1 output is defined by these two processes causing a change in the optically detected signal. A model is developed for describing such systems in an approach suitable for evaluation of the analog noise amplification properties of the gate and optimization of its functioning. The initial data are fitted for gate quality evaluation within the developed model, and then modifications are proposed and experimentally realized for improving the gate functioning.