Strategies for processing diffraction data from randomly oriented particles

TL;DR

This paper compares two methods for processing diffraction data from randomly oriented particles, concluding that intensity cross-correlation is generally less feasible than single-shot approaches.

Contribution

It provides a direct comparison showing the limitations of intensity cross-correlation methods relative to single-shot techniques for x-ray imaging.

Findings

Single-shot methods are more feasible than intensity cross-correlation.

Intensity cross-correlation often not feasible even when single-shot is.

The paper clarifies the practical limitations of these approaches.

Abstract

This note compares the single-shot and intensity cross-correlation proposals for x-ray imaging of randomly oriented particles and shows very directly that the latter will usually not be feasible even when the former is.