Holographic laser Doppler ophthalmoscopy
Manuel Simonutti, Michel Paques, J.A. Sahel, Michel Gross (LKB -, Lhomond), Benjamin Samson, Caroline Magnain, Michael Atlan
TL;DR
This paper demonstrates a novel holographic laser Doppler technique for non-invasive retinal blood flow imaging in rats, providing detailed vascular maps without external contrast agents.
Contribution
It introduces a new holographic method for retinal blood flow imaging using laser Doppler holography, enabling wide-field angiographic mapping without contrast agents.
Findings
Successful imaging of retinal blood flow in rats.
High-contrast vascular maps without exogenous markers.
Detection of blood flow fluctuations in 10 Hz to 25 kHz range.
Abstract
We report laser Doppler ophthalmoscopic fundus imaging in the rat eye with near-IR heterodyne holography. Sequential sampling of the beat of the reflected radiation against a frequency-shifted optical local oscillator is made onto an array detector. Wide-field maps of fluctuation spectra in the 10 Hz to 25 kHz band exhibit angiographic contrasts in the retinal vascular tree without requirement of an exogenous marker.
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