System Dynamics Modelling of the Processes Involving the Maintenance of the Naive T Cell Repertoire

TL;DR

This paper reviews immunosenescence and introduces a system dynamics model to understand how naive T cell maintenance affects immune aging, aiming to identify potential ways to mitigate immune system decline.

Contribution

It presents a novel system dynamics model of naive T cell maintenance processes, providing insights into immune aging mechanisms.

Findings

Preliminary simulation results demonstrate model viability.

Model highlights key factors influencing naive T cell levels.

Provides a foundation for future research on immune system rejuvenation.

Abstract

The study of immune system aging, i.e. immunosenescence, is a relatively new research topic. It deals with understanding the processes of immunodegradation that indicate signs of functionality loss possibly leading to death. Even though it is not possible to prevent immunosenescence, there is great benefit in comprehending its causes, which may help to reverse some of the damage done and thus improve life expectancy. One of the main factors influencing the process of immunosenescence is the number and phenotypical variety of naive T cells in an individual. This work presents a review of immunosenescence, proposes system dynamics modelling of the processes involving the maintenance of the naive T cell repertoire and presents some preliminary results.