Minimal Protocol for MRS Quality Control and Acceptance Test for Philips-Achieva MRS Tool

TL;DR

This paper proposes a minimal quality control protocol for Philips-Achieva MRS systems, focusing on reproducibility and performance tests to ensure accurate metabolite quantification and system stability.

Contribution

It introduces a simple, effective protocol for MRS quality control using phantom measurements, emphasizing reproducibility and realistic concentration assessment.

Findings

Fluctuations in measurements were below 9%.

Concentration quantification matched known values.

Protocol successfully identified system stability.

Abstract

Difficulties in obtaining good phantoms, improvements in technologies of voxel localization, better sequences for water and fat suppression has brought us to define a minimal Protocol of home-made quality controls of MRS systems. Measurements, defined in the proposed protocol, have, as main goal, to establish if peaks quantification predicts realistic concentration values, meaning that, the occurrence of this event is a sufficient condition to declare that MRS system works good. Moreover, stability measurements helps in a correct data understanding. It is, indeed, realistic to think that environmental condition can introduce casual errors in the working good system. Discrepancies in the working good condition, under stochastic variability (environment), have to be related to systematic errors introduced by the set of pre and/or post-processing operations and/or by any forms of MRS bad-working tool that differs from the previous. The quality control minimal protocol has been executed on a Philips-Achieva MRS system utilizing a phantom supplied by the manufacturer. The minimal protocol consists of two steps: reproducibility and performance tests. The reproducibility of the MRS measurements helps in quantifying the stability of the system. The performance test enables to establish if the system is able to reproduce concentrations in a realistic way. In both cases good results have been obtained: fluctuations of measured values are below 9% and quantification of concentration is consistent with the known values.