The effect of internal and global modes on the radial distribution function of confined semiflexible polymers

TL;DR

This paper presents an analytical model for the radial distribution function of confined semiflexible polymers, highlighting the significant impact of global modes on chain statistics under weak and intermediate confinement, validated by Monte Carlo simulations.

Contribution

The study introduces a comprehensive analytical approach that incorporates global modes into the conformational analysis of confined semiflexible polymers, improving upon previous models.

Findings

Global modes significantly affect chain statistics in weak and intermediate confinement.

Analytical results show excellent agreement with Monte Carlo simulations.

The model enhances understanding of polymer behavior in nano- and microscale confinement.

Abstract

The constraints imposed by nano- and microscale confinement on the conformational degrees of freedom of thermally fluctuating biopolymers are utilized in contemporary nano-devices to specifically elongate and manipulate single chains. A thorough theoretical understanding and quantification of the statistical conformations of confined polymer chains is thus a central concern in polymer physics. We present an analytical calculation of the radial distribution function of harmonically confined semiflexible polymers in the weakly bending limit. Special emphasis has been put on a proper treatment of global modes, i.e. the possibility of the chain to perform global movements within the channel. We show that the effect of these global modes significantly impacts the chain statistics in cases of weak and intermediate confinement. Comparing our analytical model to numerical data from Monte Carlo simulations we find excellent agreement over a broad range of parameters.