# Recent advances in understanding the role of FOXO3

## TL;DR

This review discusses recent findings on how the FOXO3 protein influences muscle protein turnover and longevity, and how microRNAs regulate it.

## Contribution

The paper highlights new insights into FOXO3's role in muscle protein regulation, longevity, and microRNA-mediated control.

## Key findings

- FOXO3 is consistently linked to longevity in in vivo models.
- FOXO3 regulates protein turnover in skeletal muscle, the body's largest protein pool.
- MicroRNAs play a role in regulating FOXO3 and influencing the cell cycle.

## Abstract

The forkhead box O3 (FOXO3, or FKHRL1) protein is a member of the FOXO subclass of transcription factors. FOXO proteins were originally identified as regulators of insulin-related genes; however, they are now established regulators of genes involved in vital biological processes, including substrate metabolism, protein turnover, cell survival, and cell death.
FOXO3 is one of the rare genes that have been consistently linked to longevity in
in vivo models. This review provides an update of the most recent research pertaining to the role of FOXO3 in (i) the regulation of protein turnover in skeletal muscle, the largest protein pool of the body, and (ii) the genetic basis of longevity. Finally, it examines (iii) the role of microRNAs in the regulation of FOXO3 and its impact on the regulation of the cell cycle.