# Widespread signals of convergent adaptation to high altitude in Asia and America

## TL;DR

A new Bayesian method detects genes involved in high altitude adaptation in human populations, revealing convergent evolution across continents.

## Contribution

A hierarchical Bayesian model that improves detection of selection markers while accounting for complex population histories.

## Key findings

- The Bayesian method is more powerful and less prone to false positives than existing approaches.
- Convergent adaptation to high altitude is common across continents.
- Two biological pathways evolved in both America and Asia to counter hypoxia effects.

## Abstract

Living at high-altitude is one of the most difficult challenges that humans had to cope with during their evolution. Whereas several genomic studies have revealed some of the genetic bases of adaptations in Tibetan, Andean and Ethiopian populations, relatively little evidence of convergent evolution to altitude in different continents has accumulated. This lack of evidence can be due to truly different evolutionary responses, but it can be also due to the low power of former studies that have mainly focused on populations from a single geographical region or performed separate analyses on multiple pairs of populations to avoid problems linked to shared histories between some populations. We introduce here a hierarchical Bayesian method to detect local adaptation that can deal with complex demographic histories. Our method can identify selection occurring at different scales, as well as convergent adaptation in different regions. We apply our approach to the analysis of a large SNP dataset from low- and high-altitude human populations from America and Asia. The simultaneous analysis of these two geographic areas allows us to identify several candidate genome regions for altitudinal selection, and we show that convergent evolution among continents has been quite common. In addition to identifying several genes and biological processes involved in high altitude adaptation, we identify two specific biological pathways that could have evolved in both continents to counter toxic effects induced by hypoxia.