Scale-free dynamics of somatic adaptability in immune system

TL;DR

This paper presents a physical model demonstrating scale-free dynamics in immune system adaptability, highlighting feedback mechanisms and discussing immunosenescence through epigenetic landscape analysis.

Contribution

It introduces a simple physical model capturing scale-free behavior and feedback balance in immune system dynamics, offering insights into memory formation and aging.

Findings

Scale-free behavior observed in the model

Balance of feedbacks leads to robustness

Discussion of immunosenescence based on epigenetic landscape

Abstract

The long-time dynamics of somatic adaptability in immune system is simulated by a simple physical model. The immune system described by the model exhibits a scale free behavior as is observed in living systems. The balance between the positive and negative feedbacks of the model leads to a robust immune system where the positive one corresponds to the formation of memory cells and the negative one to immunosuppression. Also the immunosenescence of the system is discussed based on the time-dependence of the epigenetic landscape of the adaptive immune cells in the shape space.