Distribution of Action Potential Duration and T-wave Morphology: a Simulation Study

TL;DR

This simulation study models the distribution of action potential durations and T-wave morphology in the heart, incorporating midmyocardial cells to produce realistic ECG waveforms and analyze their effects.

Contribution

Introduces a novel computer model that simulates inhomogeneous APD distribution considering M-cells, enhancing understanding of T-wave morphology in ECGs.

Findings

APD distribution affects T-wave morphology

Model produces realistic ECG waveforms

Ion channel parameter changes influence QT intervals

Abstract

The results of a simulation study of the action potential duration (APD) distribution and T-wave morphology taking into account the midmyocardial cells (M-cells) concept are described. To investigate the effect of M-cells we present a computer model in which ion channel action potential formulations are incorporated into three-dimensional whole heart model. We implemented inhomogeneous continuous action potential duration distribution based on different distributions of maximal slow delayed rectifier current conductance. Using the proposed action potential distribution procedure midmural zeniths with longest action potential length were created as islands of model cells in the depth of thickest areas of ventricular tissue. Different spatial functions on layer indexes were simulated and their influences on electrocardiogram waveforms were analyzed. Changing parameters of ion channel model we varied duration of minimal and maximal action potential and investigated T-wave amplitude, Q-Tpeak and QT intervals variations. The study demonstrated that the proposed original APD distribution is reasonable and produces realistic electrocardiographic waveforms.