From the Wobble to Reliable Hypothesis

TL;DR

This paper proposes an alternative hypothesis to the wobble theory, explaining various features of the genetic code and providing new insights into its physical mechanisms.

Contribution

It introduces a novel hypothesis that explains genetic code features better than the wobble hypothesis, offering new insights into its physical functioning.

Findings

Explains the difference between thymine and uracil.

Accounts for the encoding of tryptophan by a single codon.

Clarifies why E. coli lacks inosine in isoleucine tRNA.

Abstract

A simple explanation for the symmetry and degeneracy of the genetic code has been suggested. An alternative to the wobble hypothesis has been proposed. This hypothesis offers explanations for: i) the difference between thymine and uracil, ii) encoding of tryptophan by only one codon, iii) why E. coli have no inosine in isoleucine tRNA, but isoleucine is encoded by three codons. The facts revealed in this study offer a new insight into physical mechanisms of the functioning of the genetic code.