DNA Breathing Dynamics in the Presence of a Terahertz Field
B. S. Alexandrov, V. Gelev, A. R. Bishop, A. Usheva, and K. O., Rasmussen
TL;DR
This paper investigates how terahertz radiation influences DNA breathing dynamics, revealing that specific field amplitudes can induce local strand separations, potentially affecting gene expression and replication processes.
Contribution
It introduces a model demonstrating the threshold-dependent effects of terahertz fields on DNA dynamics, highlighting potential biological impacts.
Findings
Terahertz fields can induce local DNA strand separations.
Linear instabilities lead to dynamic dimerization.
Threshold amplitudes are required for true local openings.
Abstract
We consider the influence of a terahertz field on the breathing dynamics of double-stranded DNA. We model the spontaneous formation of spatially localized openings of a damped and driven DNA chain, and find that linear instabilities lead to dynamic dimerization, while true local strand separations require a threshold amplitude mechanism. Based on our results we argue that a specific terahertz radiation exposure may significantly affect the natural dynamics of DNA, and thereby influence intricate molecular processes involved in gene expression and DNA replication.
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