Multiphase modeling of tumor growth with matrix remodeling and fibrosis

TL;DR

This paper introduces a multiphase mathematical model for tumor growth that includes extracellular matrix remodeling and fibrosis formation, providing a detailed qualitative analysis of system equilibria and conditions for fibrosis.

Contribution

The study develops a novel multiphase model integrating matrix remodeling and fibrosis, with comprehensive analysis of tumor growth dynamics and fibrotic tissue formation.

Findings

Conditions for fibrosis occurrence identified

Qualitative analysis of homogeneous tumor growth system conducted

Equilibria characterization enhances understanding of tumor-ECM interactions

Abstract

We present a multiphase mathematical model for tumor growth which incorporates the remodeling of the extracellular matrix and describes the formation of fibrotic tissue by tumor cells. We also detail a full qualitative analysis of the spatially homogeneous problem, and study the equilibria of the system in order to characterize the conditions under which fibrosis may occur.