Use of L-system mathematics for making new subfamily members of olfactory receptor full length genes, OR1D2, OR1D4 and OR1D5

TL;DR

This paper applies L-system mathematics to identify a closely related subfamily of three highly similar human olfactory receptor genes, expanding understanding of their genetic relationships.

Contribution

It introduces a novel application of L-system mathematics to classify and relate olfactory receptor gene subfamilies based on their DNA sequences.

Findings

Identified a closely related subfamily of OR1D2, OR1D4, and OR1D5.

Demonstrated high sequence similarity among these receptors.

Showed the effectiveness of L-system mathematics in genetic classification.

Abstract

Ligands for only two human olfactory receptors are known. One of them, OR1D2, binds to Bourgeonal [Malnic B, Godfrey P-A, Buck L-B (2004) The human olfactory receptor gene family. Proc. Natl. Acad. Sci U. S. A. 101: 2584-2589 and Erratum in: Proc Natl Acad Sci U. S. A. (2004) 101: 7205]. OR1D2, OR1D4 and OR1D5 are three full length olfactory receptors present in an olfactory locus in human genome. These receptors are more than 80% identical in DNA sequences and have 108 base pair mismatches among them. We have used L-system mathematics and have been able to show a closely related subfamily of OR1D2, OR1D4 and OR1D5.