Towards Biosensing Strategies Based on Biochemical Logic Systems

TL;DR

This paper reviews recent progress in biochemical logic systems that enable high-fidelity biosensing by processing multiple signals through Boolean networks of enzymatic reactions, advancing the development of smart biosensors.

Contribution

It surveys current research and proposes future directions for creating digitally operated biosensors using biochemical logic networks for improved sensing accuracy.

Findings

Biochemical computing enables logical processing of signals.

Coupling enzymatic reactions with smart electrodes enhances biosensing.

Boolean logic networks improve sensing fidelity.

Abstract

Recent advances in biochemical computing, i.e., information processing with cascades of primarily enzymatic reactions realizing computing gates, such as AND, OR, etc., as well as progress in networking these gates and coupling of the resulting systems to smart/responsive electrodes for output readout, have opened new biosensing opportunities. Here we survey existing enabling research results, as well as ideas and research avenues for future development of a new paradigm of digitally operating biosensors logically processing multiple biochemical signals through Boolean logic networks composed of biomolecular reactions, yielding the final output signals as YES/NO responses. Such systems can lead to high-fidelity biosensing compared to common single or parallel sensing devices.