A PTAS for the Minimum Consensus Clustering Problem with a Fixed Number of Clusters
Paola Bonizzoni, Gianluca Della Vedova, Riccardo Dondi

TL;DR
This paper introduces a polynomial time approximation scheme for the Minimum Consensus Clustering problem with a fixed number of clusters, addressing its computational hardness and providing practical approximation methods.
Contribution
It presents the first PTAS for the problem with a fixed number of clusters, despite the problem being NP-hard.
Findings
PTAS exists for fixed number of clusters
NP-hardness of the restricted problem
Approximation algorithms for consensus clustering
Abstract
The Consensus Clustering problem has been introduced as an effective way to analyze the results of different microarray experiments. The problem consists of looking for a partition that best summarizes a set of input partitions (each corresponding to a different microarray experiment) under a simple and intuitive cost function. The problem admits polynomial time algorithms on two input partitions, but is APX-hard on three input partitions. We investigate the restriction of Consensus Clustering when the output partition is required to contain at most k sets, giving a polynomial time approximation scheme (PTAS) while proving the NP-hardness of this restriction.
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Taxonomy
TopicsGene expression and cancer classification · Gene Regulatory Network Analysis · Bioinformatics and Genomic Networks
