Dynamics of forced biopolymer translocation
V. V. Lehtola, R. P. Linna, K. Kaski
TL;DR
This paper uses simulations to study how biopolymers move through pores under force, revealing how forces, friction, and hydrodynamics influence translocation times and scaling behaviors.
Contribution
It provides a detailed simulation analysis explaining experimental observations and highlights the impact of hydrodynamics on translocation dynamics.
Findings
Hydrodynamics significantly reduces translocation times.
Scaling of translocation time depends on pore force and friction.
Force balance models effectively describe forced translocation.
Abstract
We present results from our simulations of biopolymer translocation in a solvent which explain the main experimental findings. The forced translocation can be described by simple force balance arguments for the relevant range of pore potentials in experiments and biological systems. Scaling of translocation time with polymer length varies with pore force and friction. Hydrodynamics affects this scaling and significantly reduces translocation times.
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