In vivo measurement of human brain elasticity using a light aspiration device

TL;DR

This study introduces a novel, sterilizable aspiration device for in vivo measurement of human brain elasticity during neurosurgery, providing new patient-specific data crucial for model-driven surgical compensation.

Contribution

The paper presents a new aspiration device capable of measuring patient-specific brain elasticity in vivo during surgery, addressing the lack of reliable mechanical data.

Findings

First in vivo measurements of human brain elasticity.

Brain tissue exhibits high softness and non-linear behavior.

Device successfully used during neurosurgery for data collection.

Abstract

The brain deformation that occurs during neurosurgery is a serious issue impacting the patient "safety" as well as the invasiveness of the brain surgery. Model-driven compensation is a realistic and efficient solution to solve this problem. However, a vital issue is the lack of reliable and easily obtainable patient-specific mechanical characteristics of the brain which, according to clinicians' experience, can vary considerably. We designed an aspiration device that is able to meet the very rigorous sterilization and handling process imposed during surgery, and especially neurosurgery. The device, which has no electronic component, is simple, light and can be considered as an ancillary instrument. The deformation of the aspirated tissue is imaged via a mirror using an external camera. This paper describes the experimental setup as well as its use during a specific neurosurgery. The experimental data was used to calibrate a continuous model. We show that we were able to extract an in vivo constitutive law of the brain elasticity: thus for the first time, measurements are carried out per-operatively on the patient, just before the resection of the brain parenchyma. This paper discloses the results of a difficult experiment and provide for the first time in-vivo data on human brain elasticity. The results point out the softness as well as the highly non-linear behavior of the brain tissue.