Analytical derivation of thermodynamic properties of bilayer membrane with interdigitation

TL;DR

This paper analytically models bilayer membranes with interdigitation, revealing significant differences in thermodynamic properties and pressure profiles compared to regular membranes, and discusses implications for membrane stability and structure.

Contribution

It introduces an analytical model of interdigitated bilayer membranes, highlighting differences in thermodynamic characteristics and pressure profiles from non-interdigitated membranes.

Findings

Lateral pressure profile at the membrane interface changes with interdigitation.

Free energy per chain increases with interdigitation compared to regular membranes.

Homogeneous interdigitation is energetically costly during chain elongation, but inhomogeneous interdigitation may occur at the nucleous boundary.

Abstract

We consider a model of bilayer lipid membrane with interdigitation, in which the lipid tails of the opposite monolayers interpenetrate. The interdigitation is modeled by linking tails of the hydrophobic chains in the opposite monolayers within bilayer as a first approximation. A number of thermodynamical characteristics are calculated analytically and compared with the ones of a regular membrane without interdigitation. Striking difference between lateral pressure profiles at the layers interface for linked and regular bilayer models is found. In the linked case, the lateral pressure mid-plane peak disappears, while the free energy per chain increases. Within our model we found that in case of elongation of the chains inside a nucleus of e.g. liquid-condensed phase, homogeneous interdigitation would be more costly for the membrane's free energy than energy of the hydrophobic mismatch between the elongated chains and the liquid-expanded surrounding. Nonetheless, an inhomogeneous interdigitation along the nucleous boundary may occur inside a ``belt'' of a width that varies approximately with the hydrophobic mismatch amplitude.