CoPreTHi: a Web tool which combines transmembrane protein segment prediction methods

TL;DR

CoPreTHi is a Java web tool that integrates multiple transmembrane segment prediction methods to improve accuracy in identifying membrane-spanning regions in proteins.

Contribution

It introduces a novel joint prediction algorithm that combines various existing methods into a single, more accurate prediction tool for transmembrane segments.

Findings

Joint prediction yields higher accuracy than individual methods

The web tool is freely accessible online

Combines multiple prediction algorithms into a unified histogram

Abstract

CoPreTHi is a Java based web application, which combines the results of methods that predict the location of transmembrane segments in protein sequences into a joint prediction histogram. Clearly, the joint prediction algorithm, produces superior quality results than individual prediction schemes. The program is available at http://o2.db.uoa.gr/CoPreTHi