Nonparametric spectral analysis with applications to seizure characterization using EEG time series

TL;DR

This paper introduces nonparametric spectral analysis techniques, including GML and GACV, for EEG data to better understand seizure dynamics, especially in nonstationary conditions, with demonstrated stability and improved performance.

Contribution

It develops novel nonparametric spectral estimation methods for stationary and locally stationary EEG signals, incorporating penalized likelihood and permutation tests for seizure analysis.

Findings

Proposed methods outperform existing spectral estimation techniques.

Effective in analyzing nonstationary EEG signals before seizures.

Applied successfully to intracranial EEG data for seizure insights.

Abstract

Understanding the seizure initiation process and its propagation pattern(s) is a critical task in epilepsy research. Characteristics of the pre-seizure electroencephalograms (EEGs) such as oscillating powers and high-frequency activities are believed to be indicative of the seizure onset and spread patterns. In this article, we analyze epileptic EEG time series using nonparametric spectral estimation methods to extract information on seizure-specific power and characteristic frequency [or frequency band(s)]. Because the EEGs may become nonstationary before seizure events, we develop methods for both stationary and local stationary processes. Based on penalized Whittle likelihood, we propose a direct generalized maximum likelihood (GML) and generalized approximate cross-validation (GACV) methods to estimate smoothing parameters in both smoothing spline spectrum estimation of a stationary process and smoothing spline ANOVA time-varying spectrum estimation of a locally stationary process. We also propose permutation methods to test if a locally stationary process is stationary. Extensive simulations indicate that the proposed direct methods, especially the direct GML, are stable and perform better than other existing methods. We apply the proposed methods to the intracranial electroencephalograms (IEEGs) of an epileptic patient to gain insights into the seizure generation process.