Phase transition in the genome evolution favours non-random distribution of genes on chromosomes

TL;DR

This paper uses Monte Carlo simulations to demonstrate how selection pressure influences the non-random distribution of genes and recombination hotspots on chromosomes, especially near critical crossover rates affecting genome survival.

Contribution

It introduces a computational model showing the impact of selection pressure on gene distribution and recombination hotspots in genome evolution near critical crossover points.

Findings

Selection pressure affects gene distribution on chromosomes.

Recombination hotspots are influenced by the crossover rate.

Gene order and location impact population survival.

Abstract

We have used the Monte Carlo based computer models to show that selection pressure could affect the distribution of recombination hotspots along the chromosome. Close to critical crossover rate, where genomes may switch between the Darwinian purifying selection or complementation of haplotypes, the distribution of recombination events and the force of selection exerted on genes affect the structure of chromosomes. The order of expression of gene s and their location on chromosome may decide about the extinction or survival of competing populations.