Dynamics and Efficiency of Brownian Rotors

TL;DR

This paper models the stochastic dynamics of Brownian rotors, exemplified by F0-ATP synthase, to understand how free energy profiles influence their efficiency and performance.

Contribution

It introduces an analytical model analyzing how free energy differences and profiles affect the dynamics and efficiency of Brownian rotors like F0-ATP synthase.

Findings

Optimal free energy profiles maximize rotor flow

Rotor efficiency depends on free energy profile arrangement

Rectification of stochastic motion influences performance

Abstract

Brownian rotors play an important role in biological systems and in future nano-technological applications. However the mechanisms determining their dynamics, efficiency and performance remain to be characterized. Here the F0 portion of the F-ATP synthase is considered as a paradigm of a Brownian rotor. In a generic analytical model we analyze the stochastic rotation of F0-like motors as a function of the driving free energy difference and of the free energy profile the rotor is subjected to. The latter is composed of the rotor interaction with its surroundings, of the free energy of chemical transitions, and of the workload. The dynamics and mechanical efficiency of the rotor depends on the magnitude of its stochastic motion driven by the free energy energy difference and its rectification on the reaction-diffusion path. We analyze which free energy profiles provide maximum flow and how their arrangement on the underlying reaction-diffusion path affects rectification and -- by this -- the efficiency.