Evolutionary game theory elucidates the role of glycolysis in glioma progression and invasion

TL;DR

This study uses evolutionary game theory to analyze how interactions between tumor cell phenotypes influence glioma progression, highlighting the role of glycolysis in promoting invasive behavior and suggesting potential therapeutic strategies.

Contribution

It introduces a model linking tumor phenotypes with evolutionary dynamics, revealing how glycolysis fosters invasion and proposing ways to inhibit this process.

Findings

Invasive phenotype emerges after glycolytic phenotype.

Glycolysis promotes tumor invasion.

Therapies increasing glycolysis cost may reduce invasiveness.

Abstract

Tumour progression has been described as a sequence of traits or phenotypes that cells have to acquire if the neoplasm is to become an invasive and malignant cancer. Although the genetic mutations that lead to these phenotypes are random, the process by which some of these mutations become successful and spread is influenced by the tumour microenvironment and the presence of other phenotypes. It is thus likely that some phenotypes that are essential in tumour progression will emerge in the tumour population only with the prior presence of other different phenotypes. In this paper we use evolutionary game theory to analyse the interactions between three different tumour cell phenotypes defined by autonomous growth, anaerobic glycolysis, and cancer cell invasion. The model allows to understand certain specific aspects of glioma progression such as the emergence of diffuse tumour cell invasion in low-grade tumours. We find that the invasive phenotype is more likely to evolve after the appearance of the glycolytic phenotype which would explain the ubiquitous presence of invasive growth in malignant tumours. The result suggests that therapies which increase the fitness cost of switching to anaerobic glycolysis might decrease the probability of the emergence of more invasive phenotypes