DNA Bubble Life Time in Denaturation
Zh.S.Gevorkian, Chin-Kun Hu
TL;DR
This study analyzes the lifetime of denaturation bubbles in DNA using the Poland-Scheraga model, revealing how homogeneity, heterogeneity, and loop entropy influence bubble stability and scaling behavior.
Contribution
It provides new insights into how DNA sequence heterogeneity and loop entropy exponent affect bubble lifetime at criticality within the Poland-Scheraga framework.
Findings
Homogeneous DNA bubbles have finite lifetime if c>2 at criticality.
Heterogeneity leads to infinite bubble lifetime in the thermodynamic limit.
Bubble lifetime scales with DNA length for c<2.
Abstract
We have investigated the denaturation bubble life time for a homogeneous as well as for a heterogeneous DNA within a Poland-Scheraga model. It is shown that at criticality the bubble life time for a homogeneous DNA is finite provided that the loop entropic exponent c>2 and has a scaling dependence on DNA length for c<2. Heterogeneity in the thermodynamical limit makes the bubble life time infinite for any entropic exponent.
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Taxonomy
TopicsDNA and Nucleic Acid Chemistry