A thermodynamic switch for chromosome colocalization
M. Nicodemi, B. Panning, and A. Prisco
TL;DR
This paper presents a thermodynamic model explaining how the concentration and affinity of mediators regulate the spontaneous colocalization of homologous DNA sequences, acting as a switch between independent and paired states.
Contribution
It introduces a general thermodynamic framework for understanding chromosome pairing, highlighting the role of diffusible mediators as a switch for DNA colocalization.
Findings
Mediator concentration controls DNA pairing states
The model predicts spontaneous regulation of DNA proximity
Thermodynamic principles explain homologous DNA colocalization
Abstract
A general model for the early recognition and colocalization of homologous DNA sequences is proposed. We show, on a thermodynamic ground, how the distance between two homologous DNA sequences is spontaneously regulated by the concentration and affinity of diffusible mediators binding them, which act as a switch between two phases corresponding to independence or colocalization of pairing regions.
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Taxonomy
TopicsDiffusion and Search Dynamics · RNA and protein synthesis mechanisms · DNA and Nucleic Acid Chemistry