Ion-beam therapy: from electron production in tissue like media to DNA damage estimations

TL;DR

This paper introduces a combined multi-scale approach to model ion-beam radiation damage, linking nanoscopic electron production to DNA damage estimations, and achieving consistency with macroscale methods.

Contribution

It presents a novel integrated method that bridges nanoscopic and macroscale models for ion-beam radiation damage analysis.

Findings

Good agreement with macroscale methods.

Reliable electron energy spectra for DNA damage estimation.

Potential for comprehensive multi-scale radiation damage modeling.

Abstract

Radiation damage induced by ion beams is traditionally treated at different levels of theoretical approaches, for the different scales and mechanisms involved.We present here details of a combined approach that, from a method at a nanoscopic scale, attempts to merge with higher scales existing results, by tuning the analytical method employed when extended to larger scale and so yielding a consistent picture of the entire process. Results will show the possibility to get a good agreement with macroscale methods and, on the other hand, to produce a reliable electron energy spectra to be used for DNA damage estimations.