Oxidative stress response: a proteomic view

TL;DR

This paper reviews how proteomics techniques have advanced the understanding of oxidative stress responses by enabling large-scale analysis of protein expression and modifications.

Contribution

It provides a comprehensive overview of proteomics applications in studying oxidative stress, highlighting recent methodological advances.

Findings

Proteomics reveals widespread protein modifications under oxidative stress.

Expression levels of many proteins are altered during oxidative stress.

Proteomics has expanded the scope of oxidative stress research.

Abstract

The oxidative stress response is characterized by various effects on a range of biologic molecules. When examined at the protein level, both expression levels and protein modifications are altered by oxidative stress. While these effects have been studied in the past by classic biochemical methods, the recent onset of proteomics methods has allowed the oxidative stress response to be studied on a much wider scale. The input of proteomics in the study of oxidative stress response and in the evidence of an oxidative stress component in biologic phenomena is reviewed in this paper.