SAPHIR - a multi-scale, multi-resolution modeling environment targeting blood pressure regulation and fluid homeostasis

TL;DR

SAPHIR is a modular, multi-scale modeling environment designed to simulate blood pressure regulation and fluid homeostasis, enabling detailed organ-level analysis while maintaining computational efficiency for potential clinical applications.

Contribution

The paper introduces SAPHIR, a novel multi-scale, modular simulation platform that integrates organ systems for blood pressure and fluid regulation, allowing flexible detailed modeling within a compact framework.

Findings

Development of a modular, multi-resolution simulation environment.

Ability to incorporate detailed submodules for specific organs.

Potential for clinical application due to fast execution.

Abstract

We present progress on a comprehensive, modular, interactive modeling environment centered on overall regulation of blood pressure and body fluid homeostasis. We call the project SAPHIR, for "a Systems Approach for PHysiological Integration of Renal, cardiac, and respiratory functions". The project uses state-of-the-art multi-scale simulation methods. The basic core model will give succinct input-output (reduced-dimension) descriptions of all relevant organ systems and regulatory processes, and it will be modular, multi-resolution, and extensible, in the sense that detailed submodules of any process(es) can be "plugged-in" to the basic model in order to explore, eg. system-level implications of local perturbations. The goal is to keep the basic core model compact enough to insure fast execution time (in view of eventual use in the clinic) and yet to allow elaborate detailed modules of target tissues or organs in order to focus on the problem area while maintaining the system-level regulatory compensations.