Microfluidic Device for Continuous Magnetophoretic Separation of Red Blood Cells

TL;DR

This paper introduces a microfluidic device that uses magnetic field gradients to continuously separate red blood cells from blood with high efficiency, enabling rapid and effective blood component separation.

Contribution

The paper presents a novel microfluidic device utilizing ferromagnetic dots and magnetic field gradients for continuous red blood cell separation, demonstrating high trapping efficiency.

Findings

95% of red blood cells are captured in the device

Effective separation under continuous flow conditions

Magnetic field gradient amplifies separation force

Abstract

This paper presents a microfluidic device for magnetophoretic separation red blood cells from blood under contionous flow. The separation method consist of continous flow of a blood sample (diluted in PBS) through a microfluidic channel which presents on the bottom "dots" of feromagnetic layer. By appling a magnetic field perpendicular on the flowing direction, the feromagnetic "dots" generates a gradient of magnetic field which amplifies the magnetic force. As a result, the red blood cells are captured on the bottom of the microfluidic channel while the rest of the blood is collected at the outlet. Experimental results show that an average of 95 % of red blood cells are trapped in the device