Theory and modeling of particles with DNA-mediated interactions

TL;DR

This paper reviews the theoretical and modeling approaches to DNA-mediated interactions in colloidal particles, covering their assembly, dynamics, and applications in nanotechnology and drug delivery.

Contribution

It introduces a comprehensive framework for understanding and designing DNA-functionalized colloids, including models for aggregation, dynamics, and self-assembly processes.

Findings

Statistical mechanical model of particle aggregation and melting.

Proposed model for reversible key-lock particle interactions.

Method for DNA scaffold-based nanoparticle self-assembly.

Abstract

In recent years significant attention has been attracted to proposals which utilize DNA for nanotechnological applications. Potential applications of these ideas range from the programmable self-assembly of colloidal crystals, to biosensors and nanoparticle based drug delivery platforms. In Chapter I we introduce the system, which generically consists of colloidal particles functionalized with specially designed DNA markers. The sequence of bases on the DNA markers determines the particle type. Due to the hybridization between complementary single-stranded DNA, specific, type-dependent interactions can be introduced between particles by choosing the appropriate DNA marker sequences. In Chapter II we develop a statistical mechanical description of the aggregation and melting behavior of particles with DNA-mediated interactions. In Chapter III a model is proposed to describe the dynamical departure and diffusion of particles which form reversible key-lock connections. In Chapter IV we propose a method to self-assemble nanoparticle clusters using DNA scaffolds. A natural extension is discussed in Chapter V, the programmable self-assembly of nanoparticle clusters where the desired cluster geometry is encoded using DNA-mediated interactions. In Chapter VI we consider a nanoparticle based drug delivery platform for targeted, cell specific chemotherapy. In Chapter VII we present prospects for future research: the connection between DNA-mediated colloidal crystallization and jamming, and the inverse problem in self-assembly.