RAId DbS: A Mass-Spectrometry Based Peptide Identification Web Server with Knowledge Integration
Gelio Alves, Aleksey Ogurtsov, and Yi-Kuo Yu
TL;DR
RAId DbS is an enhanced peptide identification web server that integrates knowledge of polymorphisms, modifications, and disease associations to improve mass spectrometry analysis in personalized proteomics.
Contribution
It introduces a web-based tool that incorporates annotated polymorphisms and modifications into peptide identification, enabling discovery of novel variants and disease-related peptides.
Findings
Supports identification of peptides with known and novel polymorphisms
Integrates disease association data for more informative analysis
Available across multiple operating systems
Abstract
Summary: In anticipation of the individualized proteomics era and the need to integrate knowledge from disease studies, we have augmented our peptide identification software RAId DbS to take into account annotated single amino acid polymorphisms, post-translational modifications, and their documented disease associations while analyzing a tandem mass spectrum. To facilitate new discoveries, RAId DbS allows users to conduct searches permitting novel polymorphisms. Availability: The webserver link is http://www.ncbi.nlm.nih.gov/ /CBBResearch/qmbp/raid dbs/index.html. The relevant databases and binaries of RAId DbS for Linux, Windows, and Mac OS X are available from the same web page. Contact: [email protected]
Peer Reviews
No public reviews on file for this paper yet. If you reviewed it on a platform where reviews are public (OpenReview, ICLR, NeurIPS, ICML), you can paste yours below so the community can read it here.
Videos
No videos yet. Explain this paper in a talk, walkthrough, or lecture? Add one.
Taxonomy
TopicsAdvanced Proteomics Techniques and Applications · Machine Learning in Bioinformatics · Mass Spectrometry Techniques and Applications