Silicon-based nanochannel glucose sensor

TL;DR

This paper presents a silicon nanochannel FET-based glucose sensor with high sensitivity, linear response in relevant concentration ranges, and potential for integration with silicon circuitry for advanced biosensing applications.

Contribution

It introduces a novel silicon nanochannel FET biosensor functionalized with glucose oxidase, demonstrating effective glucose detection with rapid response and linearity.

Findings

Linear response in 0.5-8 mM glucose range

Response time of 3-5 minutes

Potential for high-density integration

Abstract

Silicon nanochannel biological field effect transistors have been developed for glucose detection. The device is nanofabricated from a silicon-on-insulator wafer with a top-down approach and surface functionalized with glucose oxidase. The differential conductance of silicon nanowires, tuned with source-drain bias voltage, is demonstrated to be sensitive to the biocatalyzed oxidation of glucose. The glucose biosensor response is linear in the 0.5-8 mM concentration range with 3-5 min response time. This silicon nanochannel-based glucose biosensor technology offers the possibility of high density, high quality glucose biosensor integration with silicon-based circuitry.