Quantized current blockade and hydrodynamic correlations in biopolymer translocation through nanopores: evidence from multiscale simulations

TL;DR

This paper introduces a multiscale simulation approach to study biopolymer translocation through nanopores, revealing quantized current blockade and the impact of hydrodynamic correlations on translocation speed.

Contribution

It provides a novel multiscale methodology combining microscopic biopolymer modeling with mesoscopic solvent dynamics, advancing understanding of translocation mechanisms.

Findings

Quantized current blockade depends on folding configuration.

Hydrodynamic correlations accelerate translocation.

Multiscale simulations reveal detailed translocation dynamics.

Abstract

We present a detailed description of biopolymer translocation through a nanopore in the presence of a solvent, using an innovative multi-scale methodology which treats the biopolymer at the microscopic scale as combined with a self-consistent mesoscopic description for the solvent fluid dynamics. We report evidence for quantized current blockade depending on the folding configuration and offer detailed information on the role of hydrodynamic correlations in speeding-up the translocation process.