Within-host HIV models with periodic antiretroviral therapy

TL;DR

This paper analyzes how periodic antiretroviral therapy can potentially eradicate HIV within a host, providing theoretical and numerical insights into optimal treatment strategies considering toxicity constraints.

Contribution

It introduces a model for periodic HIV treatment, demonstrating eradication feasibility and simplifying optimization of drug regimens.

Findings

Eradication is possible with periodic therapy.

Optimal drug combinations can be identified efficiently.

Numerical examples illustrate practical application.

Abstract

This paper investigates the effect of drug treatment on the standard within-host HIV model, assuming that therapy occurs periodically. It is shown that eradication is possible under these periodic regimes, and we quantitatively characterize successful drugs or drug combinations, both theoretically and numerically. We also consider certain optimization problems, motivated for instance, by the fact that eradication should be achieved at acceptable toxicity levels to the patient. It turns out that these optimization problems can be simplified considerably, and this makes calculations of the optima a fairly straightforward task. All our results will be illustrated by means of numerical examples based on up-to-date knowledge of parameter values in the model.