Global dynamical model of the cardiovascular system

TL;DR

This paper develops a comprehensive global dynamical model of the human cardiovascular system to simulate blood flow and transport processes, including effects of blood loss and pathologies, integrating arterial, venous, pulmonary, and systemic circulation with heart and peripheral models.

Contribution

It introduces a novel integrated model of the entire cardiovascular system, capturing feedbacks and interdependencies across different regions for improved physiological simulations.

Findings

Model effectively simulates blood flow in the whole organism.

The model can analyze effects of blood loss and pathologies.

Provides a basis for forecasting cardiovascular responses.

Abstract

Blood system functions are very diverse and important for most processes in human organism. One of its primary functions is matter transport among different parts of the organism including tissue supplying with oxygen, carbon dioxide excretion, drug propagation etc. Forecasting of these processes under normal conditions and in the presence of different pathologies like atherosclerosis, loss of blood, anatomical abnormalities, pathological changing in chemical transformations and others is significant issue for many physiologists. In this connection should be pointed out that global processes are of special interest as they include feedbacks and interdependences among different regions of the organism. Thus the main goal of this work is to develop the model allowing to describe effectively blood flow in the whole organism. As we interested in global processes the models of the four vascular trees (arterial and venous parts of systemic and pulmonary circulation) must be closed with heart and peripheral circulation models. As one of the model applications the processes of the blood loss is considered in the end of the paper.