Across and beyond the cell are peptide strings

TL;DR

This paper challenges the traditional cell-centric view of biological phenomena, proposing peptide strings as fundamental elements that could revolutionize understanding of complex diseases beyond cellular mechanisms.

Contribution

It introduces peptide strings as a novel fundamental concept that extends beyond cells, offering new insights into complex disease mechanisms and biological organization.

Findings

Peptide strings are proposed as fundamental biological elements.

Current cell-based approaches are insufficient for complex diseases.

Peptide strings may provide new avenues for understanding disease mechanisms.

Abstract

Until presently, most approaches for understanding physiological or pathological phenomena have been based on the assumption that these processes start from individual cells, a concept introduced primarily by Virchow in the 19th century. Yet, it has also been increasingly recognized that this perception is insufficient, at least when it comes to grasping the mechanisms underlying largely incurable diseases such as metastatic cancer or rheumatoid arthritis. Despite this insight, even recently founded disciplines such as systems biology are still locked in this century-old mind-set of cellular building blocks and thus predictably of limited usefulness. Other studies conducted over the past years, however, suggest that there is something more fundamental to life and its various conditions than the cell: peptide strings. Here, I review the origin and nature of these sub- and trans-cellular elements as well as their potential to provide the long-sought answers hitherto inaccessible to cell biology.